CD28-IN-1

CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a dissociation constant (KD) of 12.48 μM. It demonstrates excellent binding affinity to CD28, effectively hindering the CD28-B7 interaction. CD28-IN-1 suppresses CD28-driven immune activation and reduces cytokine production (IFN-γ, IL-2, and TNF-α) in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. This compound is suitable for use in tumor immunology research.