FPR2 Agonist 2 is a highly potent and brain-penetrant small molecule activator of human FPR2 (EC50 = 0.13 nM). It demonstrates anti-inflammatory effects by suppressing pro-inflammatory cytokine release, protecting mitochondrial function, and reducing caspase-3 activity, making it a valuable tool for neuroinflammation and neurodegeneration research in both cellular and animal models.