Polyinosinic-polycytidylic acid sodium

SKU: orb1309224

Description

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	42424-50-0
MW	695.403
Formula	(C₁₀H₁₃N₄O₈P)x.(C₉H₁₄N₃O₈P)x.xNa
SMILES	[NaH].Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1.O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c1nc[nH]c2=O
Target	TLR,Apoptosis
Solubility	DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:90 mg/mL (129.42 mM)

Bioactivity

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In Vivo

Polyinosinic-polycytidylic acid significantly inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells, resulting in a 50% reduction in human DNA levels in treated mice.

In Vitro

Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5). The effect of polyi:c on tumor immunotherapy has been well explored for several decades. The accumulated evidence suggests that polyi:c could be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Recent studies have also shown that activation of TLR3 and RLR signaling by polyi:c can directly trigger apoptosis in some cancer cells.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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apoptosis, Apoptosis, annealing, double-stranded, dsRNA, Inhibitor, MDA5, inhibit, immunotherapy, microenvironment, Polyinosinic polycytidylic acid sodium, Polyinosinicpolycytidylic acid sodium, Polyinosinic-polycytidylic acid sodium, Polyinosinic-polycytidylic acid, Poly(I:C), Poly(I:C) sodium, Toll-like Receptor (TLR), proper, TLR, TLR3, tumor, RNA, RIG-I

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Compound Identifiers

PubChem CID

168312302 ↗

Key Properties

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No computed properties available.

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