Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

DLin-KC2-DMA

SKU: orb1308377

Description

DLin-KC2-DMA is an ionizable cationic lipid utilized for siRNA delivery in lipid nanoparticles (LNPs). It enables effective gene silencing, such as targeting GAPDH, in both in vitro and in vivo research applications for therapeutic development.

Research Area

Immunology & Inflammation, Metabolism Research

Images & Validation

Key Properties

CAS Number1190197-97-7
MW642.09
Purity97.74% (May vary between batches)
FormulaC43H79NO2
SMILESCCCCC\C=C/C\C=C/CCCCCCCCC1(CCCCCCCC\C=C/C\C=C/CCCCC)OCC(CCN(C)C)O1
TargetOthers,Liposome
SolubilityEthanol:50 mg/mL (77.87 mM);DMSO:100 mg/mL (155.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.23 mM)

Bioactivity

In Vivo
METHODS: C57Bl6 mice were injected with DLinKC2-DMA-formulated LNP siRNA (5 mg/kg, tail vein injection) via the tail vein to study the in vivo gene silencing properties of DLinKC2-DMA-formulated LNP siRNA. RESULTS DLinKC2-DMA effectively silenced target genes in APcs in vivo.
In Vitro
METHODS: Macrophages (MΦ) and dendritic cells (DC) were treated with DLinKC2-DMA (1,5μg/mL) to observe the effect of DLinKC2-DMA on siRNA-mediated gene silencing. GAPDH and control α-tubulin expression were evaluated using Western blot analysis and flow cytometry. RESULTS At a dose level of 5μg/ml, LNPs containing DLinKC2-DMA were again the most effective gene silencing agents.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DLin KC2 DMA, DLinKC2DMA, DLin-KC-2-DMA, DLin-KC2-DMA, inhibit, Inhibitor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 90.00
5 mg
$ 120.00
10 mg
$ 150.00
25 mg
$ 250.00
50 mg
$ 400.00
100 mg
$ 570.00
200 mg
$ 720.00
500 mg
$ 1,260.00
1 g
$ 1,750.00
DispatchUsually dispatched within 3-5 business days
Bulk Enquiry