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DOPE

SKU: orb1307144
FeaturedFeatured Product

Description

DOPE is a neutral helper lipid used to formulate cationic liposomes for non-viral gene delivery. It enhances transfection efficiency in both in vitro and in vivo studies by promoting membrane fusion and endosomal escape during DNA delivery applications.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number4004-05-1
MW744.03
Purity97.23%
FormulaC41H78NO8P
SMILESCCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
TargetEndogenous Metabolite,Others,Liposome
SolubilityEthanol:10 mg/mL (13.44 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
Helper lipid for liposome:
In Vitro
Each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent). Wit the neutral lipid fo the LNP is DOPE, LNP exerts knock-down (KD) effect on macrophages and DCs and Liposome-containing DOPE shows fusogenicity. LNP/siRNA significantly suppresses CD45 protein expression at an Inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.

Storage & Handling

Storagestore at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

1,2Dioleoylsnglycero3phosphoethanolamine, 1,2 Dioleoyl sn glycero 3 phosphoethanolamine, cationic, DNA, dioleoylphosphatidylethanolamine, Inhibitor, emulsifier, liposome, knock-down, inhibit, transfection, siRNA, phospholipid

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

DOPE (orb1307144)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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25 mg
¥ 1,040.00
50 mg
¥ 1,430.00
100 mg
¥ 1,820.00
500 mg
¥ 3,640.00
DispatchUsually dispatched within 3-5 working days
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