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DOPE

SKU: orb1307144

Description

DOPE is a neutral helper lipid used to formulate cationic liposomes for non-viral gene delivery. It enhances transfection efficiency in both in vitro and in vivo studies by promoting membrane fusion and endosomal escape during DNA delivery applications.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number4004-05-1
MW744.03
Purity97.23% (May vary between batches)
FormulaC41H78NO8P
SMILESCCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
TargetOthers
SolubilityEthanol:10 mg/mL (13.44 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
Helper lipid for liposome:
In Vitro
Each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent). With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effect on macrophages and DCs and Liposome-containing DOPE shows fusogenicity. LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

1,2Dioleoylsnglycero3phosphoethanolamine, 1,2 Dioleoyl sn glycero 3 phosphoethanolamine, cationic, DNA, dioleoylphosphatidylethanolamine, Inhibitor, emulsifier, liposome, knock-down, inhibit, transfection, siRNA, phospholipid

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Key Properties

No computed properties available.

Protocol Information

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100 mg
$ 140.00
DispatchUsually dispatched within 3-5 working days
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