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PF-1355

SKU: orb1304131

Description

PF-1355

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1435467-38-1
MW321.35
Purity99.93%
FormulaC14H15N3O4S
SMILESCOc1ccc(OC)c(c1)-c1cc(=O)[nH]c(=S)n1CC(N)=O
TargetGlutathione Peroxidase
SolubilityDMSO:55 mg/mL (171.15 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.22 mM)

Bioactivity

In Vivo
Administering PF-1355 orally diminishes MPO activity in plasma, lessens vascular edema and neutrophil recruitment, and increases circulating cytokines levels. PF-1355 treatment entirely inhibits albuminuria and chronic renal dysfunction in a model of anti-glomerular basement membrane disease.
In Vitro
PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC5 = .47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC5 = .03 μM).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Glutathione Peroxidase, GlutathionePeroxidase, MPO, ZINC 205721785, ZINC205721785, ZINC-205721785, PF06281355, PF-06281355, PF1355, PF-1355, PF 1355, PF 06281355
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

PF-1355 (orb1304131)

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Available Sizes

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500 mg
2 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
5 mg
¥ 1,170.00
10 mg
¥ 1,560.00
25 mg
¥ 2,080.00
50 mg
¥ 3,510.00
100 mg
¥ 4,810.00
200 mg
¥ 6,500.00