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NBC 6

SKU: orb1685255

Description

NLRP3-IN-NBC6 is a selective small molecule inhibitor of the NLRP3 inflammasome with an IC50 of 574 nM. It functions independently of calcium signaling and effectively blocks nigericin-induced activation in THP-1 cells and imiquimod-induced IL-1β release in primed BMDMs. This compound is a valuable research tool for investigating NLRP3-driven pathologies in both cellular and animal models.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number2068818-02-8
MW409.5
FormulaC18H16BCl3N2O2
SMILESC(Cl)(Cl)(Cl)C1=[NH][B+3](O=C(N)[C-]1C(C)=O)([C-]=2C=CC=CC2)[C-]=3C=CC=CC3
TargetOthers,NOD-like Receptor (NLR)

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information