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Phospho-Stat6 (Tyr641) rabbit mAb Antibody

SKU: orb1946356

Description

The transcription factor Stat6 is a member of the signal transducers and activators of transcription (STAT) family of proteins. Stat6 is the only member of this family that is activated by interleukin-4 (IL-4), after which Stat6 is both tyrosine- and serine-phosphorylated by Jak kinases. The consensus Stat6 binding site TTCN4GAA is found in the promoters of many genes regulated by IL-4. In T lymphocytes, Stat6 is required for differentiation into Th2 cells in response to IL-4. Stat6 may play a role in solid tumorigenesis; a large immunohistochemistry study of Stat6 expression in over 2,000 tumor samples confirmed strong nuclear staining.

Research Area

Cancer Biology

Images & Validation

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Tested ApplicationsFC, WB
Dilution Range1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
ReactivityHuman, Mouse

Key Properties

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HostRabbit
ClonalityMonoclonal
IsotypeRabbit IgG1k
Clone No.BI34
ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
PurificationProtein A+G
ConjugationUnconjugated

Storage & Handling

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StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Form/AppearanceLiquid
Buffer/Preservatives1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% rAlbumin
Concentration0.5 mg/mL
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Signal transducer and activator of transcription 6, IL-4 Stat

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UniProt Details

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No UniProt data available

Protocol Information

WB
Western Blot (IB, immunoblot)
View Protocol
FC
Flow Cytometry
View Protocol

Available Sizes

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20 μl
$ 370.00
200 μl
$ 910.00
Free Secondary Antibody (20 ul)0/0

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DispatchUsually dispatched within 5-10 working days
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