Melan-A/MART-1 analog

SKU: orb1942941

Description

[Leu27]-Melan-A, MART-1 (26-35), is a biologically active peptide modified by substituting leucine for alanine at position 27, which enhances its HLA-A*0201 binding, immunogenicity, and antigenicity compared to the natural peptide. Pyroglutamyl (pGlu) peptides, arising from the spontaneous cyclization of glutamine (Q) or glutamic acid (E) at the N-terminus, are a recognized subset of peptides that may confer increased stability due to the hydrophobic γ-lactam ring of pGlu. These pGlu peptides are typically included during peptide purity assessments in HPLC analysis.

Images & Validation

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Key Properties

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CAS Number	204060-45-7
MW	985.18
Formula	C₄₅H₈₀N₁₀O₁₄
SMILES	[C@@H](NC([C@@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)CC(C)C)=O)C)=O)=O)[C@H](CC)C)=O)=O)[C@H](CC)C)=O)(C(N[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)[C@@H](C)O)=O)CC(C)C

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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