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Aclacinomycin A

SKU: orb2276869

Description

Aclacinomycin A (Aclarubicin) is an anthracycline antibiotic derived from Streptomyces galilaeus that acts as a dual topoisomerase I/II inhibitor, suppressing RNA synthesis. Its research applications include studies in relapsed leukemia and advanced lymphomas, utilizing both in vitro and in vivo experimental models to investigate its antitumor mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number57576-44-0
MW811.87
Purity99.43%
FormulaC42H53NO15
SMILESC(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7
TargetDNA/RNA Synthesis,Topoisomerase,Antibiotic,Proteasome
SolubilityDMSO:30 mg/mL (36.95 mM)

Bioactivity

In Vivo
In DBA/2 and CDF1 (BALB/c×DBA/2) mice weighing 90-110 g with leukemia P-388 model, Aclacinomycin A (0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg; intraperitoneal administration daily for 10 days starting 3 hr after transplantation) inhibited tumor growth.
In Vitro
In V79 and irs-2 cells, Aclacinomycin A (0, 0.006, 0.12, 1.2, and 2.4 μM; 3 hours) inhibited the catalytic activity of topoisomerase II in a dose-dependent manner. The loss of topoisomerase II catalytic activity in Aclacinomycin A-treated cells was significant in all cases compared to untreated cells.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Aclarubicin, RNA, Topo II, Topo I

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Key Properties

No computed properties available.

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Aclacinomycin A (orb2276869)

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1 mg
¥ 4,420.00
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