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ADH-1

SKU: orb1701430

Description

ADH-1

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number229971-81-7
MW570.69
Purity99.94%
FormulaC22H34N8O6S2
SMILESCC(C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC1=O)C(N)=O)NC(C)=O
TargetCadherin
SolubilityDMSO:10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.5 mM)

Bioactivity

In Vivo
ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts.
In Vitro
ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner.

Storage & Handling

Storagekeep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ADH 1, ADH1, ADH-1, Exherin, Inhibitor, inhibit, N-cadherin

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Key Properties

No computed properties available.

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ADH-1 (orb1701430)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
¥ 1,300.00
5 mg
¥ 1,690.00
10 mg
¥ 2,080.00
25 mg
¥ 3,120.00
50 mg
¥ 4,290.00
100 mg
¥ 6,110.00
200 mg
¥ 8,710.00
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