Colistin sulfate

SKU: orb1309253

Description

Colistin sulfate (CAS 1066-17-7) is a polypeptide antibiotic complex of Polymyxins E1 and E2, derived from Bacillus colistinus. It is widely used in research for studying antimicrobial mechanisms and combating multidrug-resistant Gram-negative bacterial infections in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology

Images & Validation

−

Key Properties

−

CAS Number	1264-72-8
MW	1253.51
Purity	98.00%
Formula	C₅₃H₁₀₀N₁₆O₁₇S
SMILES	OS(O)(=O)=O.CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O
Target	Antibacterial,Autophagy,Antibiotic,Cell wall
Solubility	H2O:125 mg/mL (99.72 mM);DMSO:Insoluble

Bioactivity

−

In Vivo

Colistin (2 μg/ml) exhibits broad-spectrum antibacterial activity, effectively inhibiting most strains of Escherichia coli and Pseudomonas aeruginosa, as well as All strains o the genera Enterobacter, Salmonella, Shigella, Pasteurella, Brucella, and Bordetella. Additionally, it is active against strains o the genera Moraxella, Serratia, and Providencia. In 225 strains of P. aeruginosa the MIC90 and IC50 of Colistin are 6.3 μg mL and 1.6 μg/ml, respectively In Acinetobacter baumannii, Colistin sulfate demonstrates concentration dependent post-antibiotic effects.

Storage & Handling

−

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

−

1066-17-7, 1066-17-7 free base, Autophagy, Antibiotic, Bacterial, cell wall, Cell wall, Cellwall, Colistin sulfate, Colistin Sulfate, Colistin sulfate (1066-17-7 free base), Colistin, Inhibitor, inhibit, Polymyxin E, Polymyxin E Sulfate, Polymixin E Sulfate

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

91885449 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols