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COX-2-IN-2

SKU: orb1710642

Description

COX-2-IN-2 is a potent and selective cyclooxygenase-2 inhibitor with an IC50 of 0.24 µM. COX-2-IN-1 is an anti-inflammatory and analgesic agent. These small molecules are valuable research tools for studying inflammation, pain, and COX-2 biology in both cellular and animal models.

Research Area

Immunology & Inflammation, Neuroscience

Images & Validation

Key Properties

CAS Number134729-13-8
MW341.36
Purity98.85%
FormulaC17H12FN3O2S
SMILESC(#N)C=1C=C(N(N1)C2=CC=C(F)C=C2)C3=CC=C(S(C)(=O)=O)C=C3
TargetCOX
Solubility10% DMSO+90% Corn Oil:2 mg/mL (5.86 mM);DMSO:45 mg/mL (131.83 mM)

Bioactivity

Target IC50
COX-2:240 nM
In Vivo
COX-2-IN-2 exhibits oral ED50 values of 0.030 mg/kg for adjuvant-induced arthritis and 0.47 mg/kg for collagen-induced arthritis, with an ED30 of 7.4 mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay, demonstrating good analgesic activity and no ulcerogenicity.
In Vitro
COX-2-IN-2 demonstrates no inhibition of COX-1, even at a concentration of 100μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

COX2IN2, COX-2-IN-2, COX-2, COX 2 IN 2

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Key Properties

No computed properties available.

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COX-2-IN-2 (orb1710642)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 2,860.00
5 mg
¥ 6,240.00
1 ml x 10 mM (in DMSO)
¥ 6,370.00
10 mg
¥ 9,750.00
25 mg
¥ 18,720.00
50 mg
¥ 29,510.00
100 mg
¥ 39,000.00
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