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E3330

SKU: orb1300433

Description

E3330

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number136164-66-4
MW378.46
Purity99.52%
FormulaC21H30O6
SMILESCCCCCCCCC\C(=C/C1=C(C)C(=O)C(OC)=C(OC)C1=O)C(O)=O
TargetNF-κB,DNA/RNA Synthesis,HIF/HIF Prolyl-Hydroxylase,Reactive Oxygen Species,VEGFR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.28 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:70 mg/mL (184.96 mM);DMSO:50 mg/mL (132.11 mM)

Bioactivity

In Vivo
In mice with endotoxin-mediated hepatitis, E3330 (300 mg/kg, p.o.) attenuate the elevation of plasma tumor necrosis factor activity and protectes mice from liver injury. In Rat model, E3330 (100 mg/kg, p.o.) also protectes rats from severe liver injury induced with endotoxin plus galactosamine.
In Vitro
E3330 affects hemangioblast development in vitro via Inhibition of Ape1 redox activity. E3330 inhibit the growth of human pancreatic cancer cell line PANC1, XPA1, MIAPACA, BxPC3, and PK9. E3330 also promotes exit of cell cycle in PANC1 cells, inhibit the DNA-Binding activity of HIF-1α and migration of pancreatic cancer cells. In JHH6 cells, E3330 prevent the functional activation of NF-κB vi the alteration of APE1 subcellular trafficking and reduces IL-6 and IL-8 expression induced by TNF-α and FAs accumulation through blockage o the redox-mediated activation of NF-κB.
Cell Research
PANC1 cells are placed in one well of a 12-well plate and treated with 5 to 30 μM E3330. After a 24, 48, and 72 h of culture the cells are washed with PBS and stained with trypan blue, and cell viability is examined by countin the live cell numbers.(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Activator Protein 1, anticancer, APE1, APE1(Ref-1), AP-1, APX3330, APX-3330, APX 3330, DNASynthesis, E 3330, DNA-binding, DNA/RNA Synthesis, DNA Synthesis, HIF, HIFProlylHydroxylase, HIFs, HIF-PH, HIF/HIFProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, Hypoxia-inducible factors, HUVECs, E3330, E-3330, endonuclease, EPCs, H1975, NSCLC cells, Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, orally, neuroprotective, pancreatic cancer, PANC1, PCECs, Inhibitor, inhibit, IL-8, VEGFR, Vascular endothelial growth factor receptor, Reactive Oxygen Species, REF-1, RNA Synthesis, RNASynthesis, TNF-α
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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E3330 (orb1300433)

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Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
1 ml x 10 mM (in DMSO)
¥ 1,690.00
5 mg
¥ 1,820.00
10 mg
¥ 2,730.00
25 mg
¥ 4,420.00
50 mg
¥ 7,020.00
100 mg
¥ 10,140.00
200 mg
¥ 13,390.00
DispatchUsually dispatched within 3-5 working days
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