Ethyl cinnamate

SKU: orb1297381

Description

Ethyl cinnamate is a bioactive small molecule with demonstrated antifungal and vasorelaxant properties. Its mechanism involves inducing ROS overproduction, leading to lipid peroxidation, cell membrane damage, and metabolic disruption. Research applications include studying smooth muscle physiology, as it concentration-dependently inhibits high K+ and phenylephrine-induced contractions with IC50 values of 0.30 mM and 0.38 mM, respectively.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	103-36-6
MW	176.21
Purity	99.53%
Formula	C₁₁H₁₂O₂
SMILES	C(=CC(OCC)=O)C1=CC=CC=C1
Target	VEGFR,Parasite,ROS,NO Synthase,Calcium Channel,Apoptosis
Solubility	DMSO:50 mg/mL (283.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.35 mM)

Bioactivity

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Target IC50

Tonic contractions (chenylephrine-induced):0.38 mM|Tonic contractions (high K+-induced):0.30 mM

In Vitro

Parameters, including biomass, F(v)/F(m) (maximal photochemical efficiency of PSII), Ф(PSII) (actual photochemical efficiency of PSII in the light), FDA, and PI staining fluorescence, were measured. The results showed the following: (1) The inhibition on biomass increased as the exposure concentration increased. 1 mg/L Ethyl cinnamate was sufficient to reduce the total biomass of C. vulgaris. The 48-h and 72-h EC50 values were 2.07 mg/L (1.94-2.20) and 1.89 mg/L (1.82-1.97). (2) After 24 h of exposure to 2-4 mg/L Ethyl cinnamate, the photosynthesis of C. vulgaris almost ceased, manifesting in DФ(PSII) being close to zero. After 72 h of exposure to 4 mg/L Ethyl cinnamate, the Fv /Fm of C. vulgaris dropped to zero. (3) Ethyl cinnamate also affected the cellular physiology of C. vulgaris, but these effects resulted in the inhibition of cell yield rather than cell death

Storage & Handling

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Storage	Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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clearing, CalciumChannel, Calcium Channel, NOSynthase, Inhibitor, inhibit, NO Synthase, Ethyl cinnamate, fragrance, ROS, reagent

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Compound Identifiers

PubChem CID

7649 ↗

Key Properties

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No computed properties available.

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Ethyl cinnamate (orb1297381)

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Purity:	99.64%
CAS Number:	4192-77-2
MW:	176.21
Formula:	C₁₁H₁₂O₂

CAS Number:	155401-23-3
MW:	222.237
Formula:	C₁₂H₁₄O₄

CAS Number:	856765-68-9
MW:	181.24
Formula:	C₁₁H₁₂O₂

Purity:	>98% (HPLC)
CAS Number:	103-36-6
MW:	176.2
Formula:	C₁₁H₁₂O₂

Ethyl cinnamate

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Compound Identifiers

Key Properties

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Ethyl cinnamate (orb1297381)

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