Fluvoxamine maleate

SKU: orb1309842

Description

Fluvoxamine maleate is a selective serotonin reuptake inhibitor (SSRI) used in research on depression and anxiety disorders. It is widely applied in both in vitro binding assays and in vivo behavioral studies to investigate serotonergic neurotransmission and psychopharmacology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	61718-82-9
MW	434.41
Purity	99.97% (May vary between batches)
Formula	C₁₉H₂₅F₃N₂O₆
SMILES	c1(/C(=N/OCCN)/CCCCOC)ccc(cc1)C(F)(F)F.C(=C\C(=O)O)\C(=O)O
Target	5-HT Receptor,Serotonin Transporter
Solubility	DMSO:250 mg/mL (575.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.6 mM)

Bioactivity

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In Vivo

Fluvoxamine maleate also exhibits the antinociception in a dose-dependent manner in the paw pressure test in non-ligated mice. Fluvoxamine maleate also induces antinociceptive effect in the acute paw pressure test, and this effect is antagonized by the 5-HT3 receptor antagonist granisetron. Fluvoxamine (10 and 30 mg/kg, i.p.) enhances synaptic efficacy in the hippocampo-mPFC pathway in a dose-dependent manner in the rat hippocampo-medial prefrontal cortex (mPFC). Fluvoxamine (10 and 30 mg/kg, i.p.) suppresses long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP is completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT(4) receptor antagonist GR 113808 (20 mg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 mg/rat, i.c.v.). Fluvoxamine maleate reinforces the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution. Fluvoxamine maleate and Fluoxetine hydrochloride inhibit the contraction induced by potassium ion on the isolated rat uterus preparation with IC50 of 3.99 μM and 18.2 μM, respectively.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SLC6A4, SerotoninTransporter, Serotonin Transporter, SERT, 5HT Receptor, 5-HT, 5-HTT, 5HTReceptor, DU23000, DU-23000, DU-23000 (maleate), DU 23000, Inhibitor, Fluvoxamine maleate, Fluvoxamine, Fluvoxamine Maleate, inhibit, MK 264, MK264, MK-264

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Compound Identifiers

PubChem CID

9560989 ↗

Key Properties

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No computed properties available.

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