Futuximab Antibody

SKU: orb1980432

Description

Sym004 is a therapeutic antibody mixture comprising futuximab and zatuximab, which bind distinct EGFR epitopes. This dual-targeting approach enhances antitumor efficacy and is investigated in preclinical in vitro and in vivo studies for oncology research, particularly in EGFR-driven cancers.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1310460-85-5
MW	146.28 kDa
Purity	95.00%
Target	EGFR

Bioactivity

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In Vivo	In the EGFRwt-expressing parazacco spilurus subsp. spilurus xenograft model, Futuximab (50 mg/kg, intraperitoneal injection, twice weekly for 5 consecutive weeks) demonstrated significant antitumor activity . Read more...
In Vitro	In NR6M cells, Futuximab (20 µg/mL, 24-48 hours) induced EGFRvIII internalization and caused a slight decrease in EGFRvIII levels .

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

EGFR

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