Iluzanebart Antibody

SKU: orb1942689

Description

Iluzanebart is a human monoclonal IgG1 agonist antibody targeting TREM2, designed to enhance microglial function and survival. It serves as a research tool for modeling microglial dysfunction in neurodegenerative diseases like CSF1R-ALSP, applicable in both in vitro and in vivo experimental systems.

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	2733621-19-5
MW	144.90 kDa
Purity	95.00%
Target	Others,Serine/threonin kinase

Bioactivity

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In Vivo

Methods: Iluzanebart (1-200 mg/kg, single dose) was administered intraperitoneally to hTREM2-CV mice. The effects of Iluzanebart on microglial gene expression and proliferation were evaluated through RNA sequencing and cellular analysis. Results: Iluzanebart increased microglial proliferation and CSF1R surface levels in the mouse brain, with significant elevation in specific chemokine levels (such as IP10 and MIP1α).

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Others,Serine/threonin kinase

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