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Orforglipron

SKU: orb1709601

Description

Orforglipron (LY3502970) is an orally administered small molecule agonist of the glucagon-like peptide-1 (GLP-1) receptor. It is utilized in preclinical and clinical research for investigating therapeutic strategies in obesity and type 1 diabetes, including studies on metabolic regulation and glycemic control.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2212020-52-3
MW882.96
Purity99.80%
FormulaC48H48F2N10O5
SMILES[H][C@@]1(CCOC(C)(C)C1)c1ccc2n(c(cc2c1)C(=O)N1CCc2nn(c(c2[C@@H]1C)-n1ccn(-c2ccc3n(C)ncc3c2F)c1=O)-c1cc(C)c(F)c(C)c1)[C@]1(C[C@@H]1C)c1noc(=O)[nH]1
TargetGlucagon Receptor
SolubilityDMSO:255 mg/mL (288.8 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (3.74 mM)

Bioactivity

In Vitro
Orforglipron potently stimulates GLP-1R-induced cAMP accumulation with partial agonist activity and no detectable recruitment of GLP-1R-mediated β-arrestin was observed.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Glucagon Receptor, GLP-1 receptor, GLP-1 receptor agonist 1, GLP-1, GlucagonReceptor, LY 3502970, LY3502970, LY-3502970, Orforglipron

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Orforglipron (orb1709601)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
¥ 1,040.00
1 mg
¥ 1,300.00
5 mg
¥ 2,210.00
10 mg
¥ 3,120.00
25 mg
¥ 5,590.00
50 mg
¥ 8,060.00
100 mg
¥ 10,010.00
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