Riluzole hydrochloride

SKU: orb1909044

Description

Riluzole hydrochloride (PK 26124 hydrochloride) is an anticonvulsant compound belonging to the family of sodium channel blockers that inhibits GABA uptake.Riluzole hydrochloride is a sodium-glutamate antagonist with anticancer and neuroprotective activity and can be used to study amyotrophic lateral sclerosis and neurological disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	850608-87-6
MW	270.66
Purity	99.76%
Formula	C₈H₆ClF₃N₂OS
SMILES	Cl.Nc1nc2ccc(OC(F)(F)F)cc2s1
Target	Sodium Channel,GABA Receptor
Solubility	H2O:2 mg/mL (7.39 mM);DMSO:80 mg/mL (295.57 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.19 mM)

Bioactivity

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Target IC50	GABA receptor:43 μM
In Vivo	Riluzole hydrochloride (8 mg/kg;i.p.) can inhibit auditory and aversive emotional responses in adult rats with arthritis, but does not affect spinal withdrawal threshold. Read more...
In Vitro	Riluzole hydrochloride (20-100 μM) significantly prolonge the decay of IPSCs, resulting in almost no change in the total charge transfe.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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AQST-117 hydrochloride, GABA Receptor, GABA uptake, GABAReceptor, PK 26124 hydrochloride

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Compound Identifiers

PubChem CID

6419992 ↗

Key Properties

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No computed properties available.

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