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Silybin B

SKU: orb1684217

Description

Silybin B is a flavonolignan that inhibits raloxifene glucosalylation and exhibits antioxidant, anti-fibrinogenic, and neuroprotective activities. It has demonstrated protective effects against cisplatin-induced neurotoxicity in vivo and induces apoptosis in human chronic myeloid leukemia K562 cells in vitro.

Research Area

Cardiovascular Research, Cell Biology, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number142797-34-0
MW482.44
Purity99.99%
FormulaC25H22O10
SMILESCOc1cc(ccc1O)[C@@H]1Oc2cc(ccc2O[C@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
TargetBcr-Abl,p38 MAPK,Apoptosis,JNK,Beta Amyloid
SolubilityDMSO:225 mg/mL (466.38 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.36 mM)

Bioactivity

In Vivo
Silybin B markedly improved the behavioral abnormalities in cisplatin-treated mice and reduced LPO levels while increasing SOD, GSH, and T-AOC in mice brain tissue. Nissl staining and Tunel assay showed that silybin B alleviated cisplatin-induced hippocampal damage.
In Vitro
The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ROS, Silybin B, Silibinin B, β Amyloid, βAmyloid, BetaAmyloid, Beta Amyloid, DPPH, bAmyloid, b Amyloid, amyloid-β, Apoptosis, BcrAbl, Bcr-Abl (K562 cell line), Calcium Channel

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Silybin B (orb1684217)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

1 mg
¥ 2,210.00
5 mg
¥ 4,810.00
1 ml x 10 mM (in DMSO)
¥ 5,070.00
10 mg
¥ 7,020.00
25 mg
¥ 10,790.00