STAT5B (C) Antibody, Rabbit Polyclonal

SKU: orb67261

Description

Rabbit polyclonal to STAT5B.Signal transducer and activator of transcription 5B (STAT5B) belongs to the transcription factor STATfamily. STAT5B carries out a dual function: signal transduction and activation of transcription.STAT5B is tyrosine phosphorylated in response to signaling via activated KIT, resulting in itstranslocation to the nucleus, where it binds to the GAS element in DNA and activates PRL-inducedtranscription. STAT5B mediates cellular responses to the cytokine KITLG/SCF and other growthfactors. Defects in STAT5B are the cause of growth hormone insensitivity with immunodeficiency(GHII).

Research Area

Epigenetics

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:500-1:2000
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal region of human STAT5B
Molecular Weight	90
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-STAT5B antibody,anti-Signal transducer and activator of transcription 5B antibody

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Western blot analysis of total cell extracts from human Jurkat(Lane1) and mouse thymus(Lane2) using STAT5B antibody

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UniProt

P51692

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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