Substance P(1-7) TFA

SKU: orb1981496

Description

Substance P(1-7) TFA is a bioactive N-terminal fragment of Substance P with anti-nociceptive properties. It modulates pain signaling by inhibiting the spinal NMDA-NO pathway, countering morphine-induced hyperalgesia, and is utilized in neurological disease research involving in vivo pain models and in vitro receptor studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	2828433-22-1
MW	1014.06
Purity	98.23%
Formula	C₄₃H₆₆F₃N₁₃O₁₂
SMILES	C(C(O)=O)(F)(F)F.C([C@@H](NC(=O)[C@H]1N(C([C@H](CCCNC(=N)N)N)=O)CCC1)CCCCN)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCC2
Target	Neurokinin receptor
Solubility	H2O:40 mg/mL (39.45 mM)

Bioactivity

−

In Vivo	Injection of low doses of Substance P(1-7) TFA (1.0-4.0 pM) and concomitant administration of SP or SP(5-11) (0.1 nM) significantly inhibited aversive behaviors triggered by SP or SP(5-11). These findings suggest that endogenously generated Substance P(1-7) may play an important function in the spinal cord by modulating the action of SP or SP(5-11). Read more...

Storage & Handling

−

Storage	keep away from moisture,keep away from direct sunlight,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

134694976 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols