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TAK-448 acetate

SKU: orb1679870

Description

TAK-448 acetate (MVT-602 acetate) is a synthetic kisspeptin analog and potent KISS1R agonist. It demonstrates antitumor activity by inhibiting the proliferation of VCaP prostate cancer cells in vitro, supporting its use in prostate cancer research.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1470374-22-1
MW1285.41
Purity99.88% (May vary between batches)
FormulaC60H84N16O16
SMILESCC(O)=O.CNC(=N)NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
TargetKisspeptin
SolubilityDMSO:80 mg/mL (62.24 mM);H2O:30 mg/mL (23.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (2.57 mM)

Bioactivity

Target IC50
KISS1R:632 pM|KISS1R:460 pM
In Vivo
A single injection of TAK-448 significantly increases plasma levels of follicle-stimulating hormone and testosterone (T) in male rats. In the androgen-sensitive prostate cancer model of male rats with VCaP xenografts, TAK-448 (0.01, 0.03, 0.3, 3 mg/kg; i.h.; 0,28 days) exhibits greater anti-tumor effects.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KISS1R, MVT 602 Acetate, MVT602 Acetate, MVT-602 acetate, TAK-448 Acetate, TAK-448 acetate (1234319-68-6 Free base)
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

TAK-448 acetate (orb1679870)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,820.00
5 mg
¥ 3,770.00
10 mg
¥ 5,720.00
25 mg
¥ 8,970.00
50 mg
¥ 12,480.00
DispatchUsually dispatched within 5-10 working days
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