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Antiangiogenic agent 7

SKU: orb2802393

Description

Compound 1 is a potent small molecule anticancer agent that induces apoptosis and elevates ROS by inhibiting thioredoxin reductase. It demonstrates in vitro cytotoxicity against HeLa, PC-3, and A549 cell lines (IC50 0.08-3.5 µM) and suppresses tumor growth in mouse xenograft models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number2527888-07-7
MW647.46
FormulaC24H26AuN3P2S
SMILESS=P(C=1C=CC=CC1)(C=2C=CC=CC2)C=3C=CC=C[C-]3[Au+][P]45CN6CN(CN(C6)C4)C5
TargetApoptosis,Reactive Oxygen Species

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

Antiangiogenic agent 7 (orb2802393)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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