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Neurokinin A TFA

SKU: orb1981721

Description

Neurokinin A TFA is the endogenous agonist for the NK-2 receptor, modulating neural, inflammatory, and nociceptive pathways. It is a key research tool for studying conditions like asthma, IBD, and chronic pain in both cellular assays and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2828433-19-6
MW1247.34
Purity98.70%
FormulaC52H81F3N14O16S
SMILESC(C(O)=O)(F)(F)F.[C@H](CC1=CC=CC=C1)(C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)C(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)N)=O)CCCCN)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O
TargetNeurokinin receptor
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (2.65 mM);DMSO:80 mg/mL (64.14 mM);H2O:40 mg/mL (32.07 mM)

Bioactivity

In Vitro
Neurokinin A TFA is a peptide neurotransmitter belonging to the tachykinin family. All tachykinins share a conserved COOH-terminal structure of Phe-X-Gly-Leu-Met-NH₂, and the most representative members of this family are Substance P and Neurokinin A. Neurokinin A TFA may act as a crucial mediator in human airway and gastrointestinal tissues. It exerts its effects through NK-2 receptors localized on smooth muscle cells and is pharmacologically coupled to GTP-binding proteins. Neurokinin A TFA is associated with both the central and peripheral nervous systems and exhibits a broad tissue distribution pattern.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NKA TFA, Neurokinin α TFA, Neuromedin L TFA, Substance K TFA

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Key Properties

No computed properties available.

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Neurokinin A TFA (orb1981721)

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% DMSO +
%+
% Tween 80 +
%

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1 mg
¥ 1,300.00
5 mg
¥ 2,210.00
10 mg
¥ 3,380.00
25 mg
¥ 5,200.00
50 mg
¥ 7,540.00
100 mg
¥ 10,400.00
200 mg
¥ 13,390.00
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