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Raloxifene

SKU: orb1705643

Description

Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections.

Research Area

Metabolism Research

Images & Validation

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Raloxifene

Key Properties

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CAS Number84449-90-1
MW473.58
Purity99.39%
FormulaC28H27NO4S
SMILESO=C(C1=CC=C(OCCN2CCCCC2)C=C1)C3=C(SC4=CC(O)=CC=C43)C=5C=CC(O)=CC5
TargetEstrogen Receptor/ERR
SolubilityEthanol:9 mg/mL (19 mM);DMSO:80 mg/mL (168.93 mM)

Bioactivity

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In Vivo
Raloxifene (10 mg/kg) induced significant reductions of urea and creatinine, TNF-α, IL-1β and caspase-3 in renal isis-reperfusion injury mouse models, suggesting renal protection. Treatment with Raloxifene (10 mg/kg) alleviates vision defects caused by initial cell injury (OBI) and may be associated with a reduction in the proinflammatory effects of microglia.
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In Vitro
Raloxifene (10 μM and 50 μM) treated cells showed an increase in the percentage of cells with fragmented nuclei of 31 to 41 percent and 45 to 66 percent, respectively, after 12 and 24 hours of exposure. Treatment with Raloxifene (50 μM) resulted in increased autophagy activity in host cells, helping to prevent intracellular bacterial invasion and proliferation. Treatment with Raloxifene((40-100 μM) prevented the dissolution of stress particles (SG) and promoted cell death during hypoxia of U251 and U3024 primary glioblastoma (GBM) cells.
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Storage & Handling

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Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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breast, cancer, bone, osteoporosis, ovariectomized, inhibit, Keoxifene, LY156758, LY-156758, LY156758 free base, LY139481, LY-139481, LY1 39481, LY 156758, LY 139481, loss, ERR, Estrogen Receptor/ERR, EstrogenReceptor, Estrogen Receptor, Inhibitor, SERM, Raloxifene, Raloxifenum, Pharoxifene, rats

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Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
5035 ↗

Key Properties

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No computed properties available.

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Raloxifene (orb1705643)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
10 mg
¥ 1,820.00
25 mg
¥ 3,120.00
50 mg
¥ 4,420.00
100 mg
¥ 6,500.00
200 mg
¥ 9,100.00
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