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2-APQC

SKU: orb2646181

Description

2-APQC is an orally active, selective SIRT3 agonist (Kd=2.756 µM) that promotes mitochondrial homeostasis. It has demonstrated efficacy in reducing myocardial hypertrophy and fibrosis in both in vivo and in vitro models, making it a valuable tool for studying heart failure and related cardiometabolic diseases.

Research Area

Epigenetics & Chromatin, Molecular Biology

Images & Validation

Key Properties

CAS Number500271-63-6
MW405.47
Purity99.88%
FormulaC23H24FN5O
SMILESO=C(NCCCCC)C=1C=2N=C3C=CC=CC3=NC2N(C1N)CC4=CC=C(F)C=C4
TargetSirtuin
SolubilityDMSO:40 mg/mL (98.65 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.93 mM)

Bioactivity

Target IC50
SIRT3:2.756 (Kd)
In Vivo
In the isoproterenol-induced rat heart failure model of Parazacco spilurus subsp. spilurus, 2-APQC (10-30 mg/kg, intragastric administration, once daily for 4 weeks) improved cardiac ejection fraction (EF) and fractional shortening (FS), reduced left ventricular end-systolic diameter (LVESD) and brain natriuretic peptide (BNP) levels, while alleviating myocardial hypertrophy and fibrosis, and downregulating the expression of myocardial injury markers such as serum lactic acid dehydrogenase (LDH) and aspartate aminotransferase (AST) . In the ISO-induced heart failure model of wild-type male mice, 2-APQC (42 mg/kg, intraperitoneal injection, once daily for 4 weeks) improved cardiac function and alleviated myocardial injury, but this protective effect was completely abolished in SIRT3 knockout mice .
In Vitro
In H9c2 cells, 2-APQC (1, 10, and 100 μM, 24 hours) concentration-dependently activated SIRT3 deacetylation activity . In H9c2 cells, 2-APQC (10 μM, 24 hours) reduced AcK68-MnSOD2, AcK122-MnSOD2, and acetylated lysine levels without significantly affecting SIRT3 protein expression . In H9c2 cells, pretreatment with 2-APQC (1-100 μM) for 24 hours followed by Isoproterenol treatment for 48 hours ameliorated Isoproterenol-induced decline in cell viability. At 10 μM, it alleviated cardiomyocyte hypertrophy and reduced the expression of α-SMA and collagen I .

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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2-APQC (orb2646181)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,430.00
5 mg
¥ 2,470.00
1 ml x 10 mM (in DMSO)
¥ 2,730.00
10 mg
¥ 3,640.00
25 mg
¥ 5,720.00
50 mg
¥ 7,930.00
100 mg
¥ 10,790.00
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