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Abd110

SKU: orb2567127

Description

Abd110 (compound 42i) is a PROTAC molecule derived from lenalidomide that selectively degrades ATR kinase. It effectively reduces both total and phosphorylated ATR levels without affecting ATM or DNA-PKcs, making it a valuable tool for studying ATR's role in DNA damage response pathways in cellular and biochemical assays.

Research Area

Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number3021581-79-0
MW790.89
FormulaC41H42N8O7S
SMILESO=C(NC=1C=CC=CC1)C=2N=C(C=NC2N)C3=CC=C(C=C3)S(=O)(=O)NCCCCCC(=O)NCCCC#CC4=CC=CC=5C(=O)N(CC45)C6C(=O)NC(=O)CC6
TargetPROTACs,ATM/ATR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Abd110 (orb2567127)

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