beta-Neoendorphin acetate(77739-21-0 free base)

SKU: orb1296319

Description

Beta-Neoendorphin acetate is a synthetic peptide agonist of the κ-opioid receptor (KOR). It is used in research to study KOR signaling pathways, analgesia, and neuropsychiatric effects in both in vitro binding assays and in vivo animal models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	78658-39-6
MW	1160.34
Purity	99.91%
Formula	C₅₆H₈₁N₁₃O₁₄
SMILES	CC(C[C@H](NC([C@@H](NC(CNC(CNC([C@@H](N)CC1=CC=C(O)C=C1)=O)=O)=O)CC2=CC=CC=C2)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(O)=O)=O)CC4=CC=C(O)C=C4)=O)CCCCN)=O)CCC/N=C(N)\N)=O)C.CC(O)=O
Target	MMP,ERK,Opioid Receptor
Solubility	DMSO:10 mM

Bioactivity

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In Vitro

β-neoendorphin (β-NEP) accelerated wound repair through activation of mitogen-activated protein kinase (MAPK)/Erk1/2 signaling pathways in human keratinocytes. Moreover, the wound healing effect of β-NEP is mainly through the acceleration of keratinocyte migration without affecting cell proliferation. Therefore, our studies reveal that β-NEP plays an important role in the regulation of wound repair and suggest a therapeutic strategy to promote wound healing using β-NEP.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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beta Neoendorphin acetate(77739 21 0 free base), b-Neoendorphin acetate(77739-21-0 free base), betaNeoendorphin acetate(77739210 free base), beta-Neoendorphin acetate(77739-21-0 free base), OpioidReceptor, Opioid Receptor, β-Neoendorphin acetate(77739-21-0 free base), κ-opioid receptor

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Compound Identifiers

PubChem CID

155977615 ↗

Key Properties

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No computed properties available.

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