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BI-3663

SKU: orb1988674

Description

BI-3663 is a potent and selective PROTAC degrader of PTK2/FAK, achieving degradation with an IC50 of 18 nM by recruiting cereblon E3 ligase. This molecule, derived from BI-4464 and pomalidomide, has demonstrated anti-cancer activity in cellular assays and is a valuable chemical probe for investigating FAK-dependent oncology and metastasis research.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2341740-84-7
MW917.84
FormulaC44H42F3N7O12
SMILESO=C(NCCOCCOCCOCCC(=O)NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(NC5=NC=C(C(=N5)OC6=CC=CC7=C6C(=O)CC7)C(F)(F)F)C(OC)=C4
TargetFAK,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

BI-3663 (orb1988674)

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