BNTA

SKU: orb1690343

Description

BNTA is a small molecule ECM modulator that alleviates arthritis in rat models by upregulating SOD3 in chondrocytes. This action scavenges superoxide anions, promoting chondrogenesis and the synthesis of cartilage structural molecules, making it a relevant tool for osteoarthritis and cartilage regeneration research.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	685119-25-9
MW	456.76
Purity	99.82%
Formula	C₁₇H₁₁BrClNO₃S₂
SMILES	Clc1ccccc1C(=O)Nc1c(Br)scc1S(=O)(=O)c1ccccc1
Target	Reactive Oxygen Species,ROS
Solubility	DMSO:60 mg/mL (131.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.38 mM)

Bioactivity

−

In Vivo

BNTA (0.015-1.5 mg/kg; intra-articular injection; twice a week for 4 and 8 weeks; Male SD rats) was well tolerated and reduced post-traumatic osteoarthritis progression following anterior cruciate ligament transection (ACLT) in rats.

In Vitro

BNTA (0.01-10 μM; 1-7 days) exhibits no reduction in cell viability for human osteoarthritis chondrocytes and primary chondrocytes isolated from rats. BNTA (0.1 μM; 2 days) induces a significant elevation in SOX9 protein expression. Notably, BNTA markedly enhances the protein levels of COL2A1 and SOX9 in rat osteoarthritis (OA) chondrocytes induced by IL1β. BNTA (0.01-10 μM; 6 hours) enhances the expression levels of extracellular matrix (ECM)-related genes, including COL2A1, ACAN, proteoglycan 4 (PRG4), and SRY-box 9 (SOX9) in human osteoarthritis (OA) chondrocytes. In IL1β-induced rat OA chondrocytes, BNTA elevates Col2a1, Acan, Prg4, and Sox9 mRNA levels, with the most significant effects observed around 0.1 μM. BNTA (10 μM; 5 days) increases proteoglycan staining in ATDC5 cells. BNTA (0.01-1 μM; 2 or 3 weeks) enhances anabolism and inhibits inflammatory response in osteoarthritis cartilage explants.

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

BNTA, ReactiveOxygenSpecies, Reactive Oxygen Species

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

2819453 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

BNTA (orb1690343)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Applications:	ELISA, NeA
Reactivity:	Bacteria
Species/Host:	Human
Clonality:	Monoclonal
Conjugation:	Unconjugated

Applications:	ELISA, NeA
Reactivity:	Bacteria
Species/Host:	Human
Clonality:	Monoclonal
Conjugation:	Unconjugated

BNTA

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Clostridium botulinum botA/BoNT Human Monoclonal Antibody [orb2959288]

Clostridium botulinum botA/BoNT Human Monoclonal Antibody [orb2959289]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

BNTA (orb1690343)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors