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CE-245677

SKU: orb1308468

Description

CE-245677

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number717899-97-3
MW513.38
Purity99.23%
FormulaC24H22Cl2N6O3
SMILESCOc1ccc(cc1NC(=O)Nc1ccc(Cl)cc1Cl)C(=O)c1cn(C(C)C)c2ncnc(N)c12
TargetTie-2,Trk receptor
SolubilityDMSO:125 mg/mL (243.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.79 mM)

Bioactivity

Target IC50
Tie2:4.7 nM|TrkB:1 nM|TrkA:1 nM
In Vivo
In vivo rat, CE-245677 displays good oral absorption PK studies (F=80%).
In Vitro
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases, with cellular IC50 values of 4.7 and 1 nM, respectively. It exhibits over 100-fold selectivity against various other angiogenic receptor tyrosine kinases, including KDR, PDGFR, and FGFR.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, CE245677, CE-245677, CE 245677, Tie2, Tie-2, Trk Receptor, Trk receptor, TrkA, TrkB, Trkreceptor, Tropomyosin related kinase receptor

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Key Properties

No computed properties available.

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Protocol Information

CE-245677 (orb1308468)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,300.00
2 mg
¥ 1,560.00
5 mg
¥ 2,210.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 3,120.00
25 mg
¥ 4,810.00
50 mg
¥ 6,500.00
100 mg
¥ 9,360.00
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