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CTX-471 Antibody

SKU: orb1980709

Description

CTX-471 is a humanized CD137 agonist antibody with high affinity for human, cynomolgus, and murine targets. It potently activates T cells and NK cells, making it a valuable tool for immuno-oncology research in both in vitro functional assays and in vivo tumor model studies.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2377152-49-1
MW146.06 kDa
Purity95.00%
TargetImmunology/Inflammation related

Bioactivity

In Vivo
Intraperitoneal administration of CTX-471 at a dose of 150 μg demonstrated curative activity as monotherapy across multiple syngeneic tumor models, exhibiting the unique advantage of achieving complete recovery in mice bearing large tumors. When administered via intravenous injection (10-80 mg/kg, on days 0, 7, 14, and 21), CTX-471 showed good tolerability with no significant signs of hepatotoxicity observed even at high doses .
In Vitro
CTX-471 (0.1-100 nM, 1 μg/mL and 10 μg/mL, 3 days) can promote IFN-γ secretion by T cells derived from Homo sapiens in an Fcγ receptor-dependent manner .

Storage & Handling

StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CTX 471, CTX471

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Protocol Information

CTX-471 Antibody (orb1980709)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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1 mg
¥ 6,370.00
5 mg
¥ 15,600.00
10 mg
¥ 24,570.00
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