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CVN424

SKU: orb1298165

Description

CVN424 is a novel, selective inverse agonist of the GPR6 receptor. It has demonstrated efficacy in preclinical models of Parkinson's disease, showing potential for modulating striatal pathways in both in vitro assays and in vivo rodent studies.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2254706-21-1
MW473.52
Purity99.02%
FormulaC24H29F2N5O3
SMILESCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@@H]3CCOC3)nc2C1
TargetGPCR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.22 mM);DMSO:49 mg/mL (103.48 mM)

Bioactivity

In Vivo
CVN424 is brain-penetrant and shows dose-dependent receptor occupancy that attained brain 50% of receptor occupancy at plasma concentrations of 6.0 and 7.4 ng/ml in mice and rats, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

disease, CVN 424, CVN424, CVN-424, brain, Inhibitor, GPR6, inhibit, orally, Parkinson, penetrant

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    C24H29F2N5O3

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Key Properties

No computed properties available.

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Protocol Information

CVN424 (orb1298165)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,820.00
5 mg
¥ 3,900.00
1 ml x 10 mM (in DMSO)
¥ 4,030.00
10 mg
¥ 5,720.00
25 mg
¥ 9,230.00
50 mg
¥ 12,870.00
100 mg
¥ 17,160.00
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