DAMGO

SKU: orb1302927

Description

DAMGO (DAGO) is a selective μ-opioid receptor agonist used in research as a potent analgesic prototype. It is extensively applied in both in vitro binding assays and in vivo studies investigating pain modulation, locomotion, and opioid receptor signaling pathways in rodent models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	78123-71-4
MW	513.59
Purity	98.83%
Formula	C₂₆H₃₅N₅O₆
SMILES	C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Target	Opioid Receptor
Solubility	DMSO:145 mg/mL (282.33 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.89 mM)

Bioactivity

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Target IC50

μ opioid receptor (Native):3.46±0.84 nM (Kd)

In Vivo

(1) DAMGO inhibits GABAergic inputs in VTA-DA neurons at presynaptic sites; (2) effect of DAMGO on GABAergic inputs in VTA-DA neurons is inhibited by potassium channel blocker 4-aminopyridine (4-AP) and Gi protein inhibitor N-ethyl maleimide (NEM); (3) phospholipase A2 (PLA2) does not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons, but mediates it in the periaqueductal gray (PAG); (4) multiple downstream signaling molecules of l receptors do not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons. These results suggest that DAMGO depresses inhibitory synaptic transmission via l receptor-Gi protein-Kv channel pathway in VTA-DA neurons, but via l receptor-PLA2 pathway in PAG

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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RX783006, RX-783006, RX 783006, μ-opioid receptor, μ-OPR, DAGO, Dagol, DAMGO, analgesic effect, OpioidReceptor, Opioid Receptor

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Compound Identifiers

PubChem CID

5462471 ↗

Key Properties

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No computed properties available.

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DAMGO (orb1302927)

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Purity:	> 95%
MW:	513.0
Source:	Synthetic

Purity:	≥95%
MW:	513

Purity:	98.59%
CAS Number:	144734-36-1
MW:	429.49
Formula:	C₂₂H₂₆FNO·C₂H₂O₄

Purity:	99.76%
MW:	627.6
Formula:	C₂₈H₃₆F₃N₅O₈

DAMGO

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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