Denosumab Antibody

SKU: orb1297798

Description

Denosumab is a human monoclonal antibody administered via subcutaneous injection. It functions by binding to and inhibiting RANKL, thereby suppressing osteoclast formation and activity. This mechanism is utilized in research models of osteoporosis, bone metastasis, and rheumatoid arthritis to study bone resorption pathways.

Research Area

Cell Biology, Protein Biochemistry, Signal Transduction

Images & Validation

−

Key Properties

−

Target	NF-κB,Caspase,Apoptosis,RANKL/RANK
Molecular Weight	144.71 kDa
Purity	99.90% (May vary between batches)
Conjugation	Unconjugated

Storage & Handling

−

Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Concentration	62.5 mg/mL
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Denosumab, Cancer, Inhibitor, inhibit, Immunoglobulin G 2, Immunoglobulin G2, Immunoglobulin G-2, Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, Osteoporosis, Ranmark, RANKL, RANK

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

NF-κB,Caspase,Apoptosis,RANKL/RANK

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols