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GNF-2

SKU: orb1224018

Description

A potent, allosteric, non-ATP competitive Bcr-Abl inhibitor that shows exclusive antiproliferative activity toward Bcr-abl-transformed cells; causes growth inhibition of Bcr-Abl positive cell lines with IC50s of 273 nM (K562) and 268 nM (SUP-B15); inhibits mutant Bcr-Abl E255V, Y253H cell growth.

Images & Validation

Key Properties

CAS Number778270-11-4
MW374.3166
Purity>98% (HPLC)
FormulaC18H13F3N4O2
SMILESO=C(N)C1=CC=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=C1
TargetBcr-Abl
SolubilityDMSO: ≥ 45 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GNF 2 | GNF2

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GNF-2 (orb1224018)

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Available Sizes

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200 mg
500 mg
2 mg
¥ 1,040.00
5 mg
¥ 1,430.00
10 mg
¥ 2,080.00
25 mg
¥ 3,770.00
50 mg
¥ 6,500.00
100 mg
¥ 9,490.00