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ITK degrader 1

SKU: orb1982567

Description

ITK Degrader 1, a highly selective interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice) degrader, induces rapid and prolonged degradation of ITK and effectively suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibody in vivo. Additionally, it demonstrates favorable plasma exposure levels.

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Key Properties

MW943.02
FormulaC48H57F3N10O7
TargetTyrosine Kinases,Others

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

ITK degrader 1 (orb1982567)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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