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NGB 2904

SKU: orb1304984

Description

NGB 2904 is a highly selective dopamine D3 receptor antagonist with a Ki of 1.4 nM, exhibiting over 150-fold selectivity versus the D2 receptor. It potently inhibits quinpirole-stimulated mitogenesis (IC50 = 6.8 nM) and is a valuable research tool for investigating D3 receptor function in neuropsychiatric disorders and addiction models, both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number189060-98-8
MW494.46
Purity99.35% (May vary between batches)
FormulaC28H29Cl2N3O
SMILESClc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Target5-HT Receptor,Dopamine Receptor
SolubilityDMSO:16.25 mg/mL (32.86 mM)

Bioactivity

Target IC50
D1:> 10000 nM(Ki)|D5:> 10000 nM(Ki)|5-HT2:223 nM(Ki)|α1-adrenoceptor:642 nM(Ki)|D4:> 5000 nM(Ki)|D2:217 nM(Ki)|D3:1.4 nM(Ki)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

5HTReceptor, addiction, 5-HT2, 5HT Receptor, D1, D2, D4, D3, D5, DopamineReceptor, Dopamine Receptor, Dopamine, cocaine, NGB2904, NGB-2904, α1 receptor

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

NGB 2904 (orb1304984)

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% Tween 80 +
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Available Sizes

Select a size below

500 mg
2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
10 mg
¥ 1,690.00
25 mg
¥ 2,730.00
50 mg
¥ 4,420.00
100 mg
¥ 5,980.00