Sifalimumab Antibody

SKU: orb1980683

Description

Sifalimumab (MEDI-545) is a human monoclonal antibody that neutralizes interferon-alpha (IFNα) to modulate aberrant immune responses. It has been investigated in clinical and preclinical research for systemic lupus erythematosus (SLE), with studies exploring its effects on disease biomarkers in both in vitro assays and in vivo models.

Research Area

Immunology & Inflammation, Neuroscience

Images & Validation

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Key Properties

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CAS Number	1006877-41-3
MW	144.24 kDa
Purity	100% (SEC-HPLC)
Target	IFNAR,COX

Bioactivity

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In Vivo	Treatment with sifalimumab at doses of 30 mg/kg (subcutaneous injection) and 3 μg/g demonstrates a therapeutic effect and attenuates lymphocyte infiltration. Read more...
In Vitro	Attenuating lymphocyte cytotoxicity co-cultured with U-87MG, sifalimumab is effective at concentrations ranging from 3 to 36 μg/well when applied for 72 hours. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MEDI-545, MDX-1103, IFN-α

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Gene Symbol

IFNAR,COX

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