(S,R,S)-AHPC-C4-NH2 hydrochloride

SKU: orb1706404

Description

This compound is a synthesized PROTAC linker conjugate featuring the (S,R,S)-AHPC VHL E3 ligase ligand. It serves as a key component for constructing PROTAC molecules, which are used in vitro and in vivo to induce targeted protein degradation for research in oncology and disease biology.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2245697-83-8
MW	566.16
Purity	95.05%
Formula	C₂₇H₄₀ClN₅O₄S
SMILES	CC(C)(C)[C@@H](C(N(C[C@@H](C1)O)[C@@H]1C(NCc(cc1)ccc1-c1c(C)ncs1)=O)=O)NC(CCCCN)=O.Cl
Target	Ligands for E3 Ligase,E3 Ligase Ligand-Linker Conjugates
Solubility	H2O:50 mg/mL (88.31 mM);DMSO:109.6 mg/mL (193.58 mM)

Bioactivity

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In Vitro	PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. Read more...

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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VHL, VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, VH032-C4-NH2 Hydrochloride, (S,R,S)AHPCC4NH2 hydrochloride, (S,R,S) AHPC C4 NH2 hydrochloride, AHPC-C4-NH2 Hydrochloride, Ligand for E3 Ligase, LigandforE3Ligase, inhibit, Inhibitor, E3 Ligase Ligand-Linker Conjugates, E3 ligase Ligand-Linker Conjugates 28

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Compound Identifiers

PubChem CID

134160245 ↗

Key Properties

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No computed properties available.

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