Vardenafil

SKU: orb1710756

Description

Vardenafil (Vivanza) is a selective PDE5 inhibitor used for erectile dysfunction research. By blocking cGMP degradation, it enhances the nitric oxide-mediated signaling pathway crucial for penile smooth muscle relaxation. This mechanism is studied in both in vitro enzymatic assays and in vivo models of erectile function.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	224785-90-4
MW	488.60
Purity	99.88% (May vary between batches)
Formula	C₂₃H₃₂N₆O₄S
SMILES	C(CC)C=1N2C(C(=O)N=C(N2)C3=C(OCC)C=CC(S(=O)(=O)N4CCN(CC)CC4)=C3)=C(C)N1
Target	Endogenous Metabolite,PDE
Solubility	DMSO:45 mg/mL (92.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.09 mM)

Bioactivity

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Target IC50	PDE4:>1000 nM\|PDE1:180 nM\|PDE5:0.7 nM\|PDE3:>1000 nM\|PDE6:11 nM
In Vivo	Vardenafil significantly induces relaxation of trabecular smooth muscle elicited by both acetylcholine and electrical stimulation. It competitively inhibits phosphodiesterase type 5 (PDE5), thus enhancing the accumulation and relaxation effect of cyclic guanosine monophosphate (cGMP) in vascular smooth muscle. Its IC50 for specifically inhibiting PDE5-mediated cGMP hydrolysis is 0.7 nM (6.6 nM). At 3 nM (10 nM), Vardenafil notably potentiates the relaxation of human trabecular smooth muscle induced by SNP. At 100 mM, Vardenafil significantly increases cGMP levels in rat hippocampus. Read more...
In Vitro	Vardenafil, through the mechanism of mitochondrial K(ATP) channel opening, protects against myocardial ischemia due to reperfusion injury. Oral administration of 3 mg/kg Vardenafil alters object recognition capability in rats. A dose of 30 mg/L orally also upregulates iNOS and proliferating cell nuclear antigen expression (replication of SM cells), leading to the normalization of the rate of dynamic corporal tissue fusion decline and the SM/collagen ratio. Furthermore, Vardenafil induces robust preconditioning-like cardioprotective effects against ischemia/reperfusion injury in rabbits by opening mitochondrial K(ATP) channels. Additionally, it dose-dependently induces an erectile response in rabbits when administered intravenously with Nitroprusside sodium. Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Zucker diabetic fatty (ZDF) rats, Vardenafil, Vivanza, stimulation, phosphodiesterase, PED5, cGMP, PDE1, impotence, hepatitis, Levitra, erectile, erectile dysfunction

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Compound Identifiers

PubChem CID

135400189 ↗

Key Properties

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No computed properties available.

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Vardenafil (orb1710756)

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CAS Number:	224788-34-5
MW:	459.56
Formula:	C₂₂H₂₉N₅O₄S

CAS Number:	147676-66-2
MW:	354.40
Formula:	C₁₉H₂₂N₄O₃

CAS Number:	1261351-28-3
MW:	466.58
Formula:	C₂₅H₃₄N₆O₃

Purity:	99.89% (May vary between batches)
CAS Number:	330808-88-3
MW:	579.11
Formula:	C₂₃H₃₂N₆O₄S·HCl·3H₂O

Purity:	99.94% (May vary between batches)
CAS Number:	224785-91-5
MW:	525.06
Formula:	C₂₃H₃₃ClN₆O₄S

Vardenafil

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Vardenafil (orb1710756)

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