Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

WAY-100635 Maleate

SKU: orb1223433

Description

WAY100635 Maleate is a potent, silent antagonist of serotonin 5-HT1A receptors.

Images & Validation

Key Properties

CAS Number1092679-51-0
MW538.64
Purity>98% (HPLC)
FormulaC25H34N4O2·C4H4O4
SMILESO=C(O)/C=C\C(=O)O.COc4ccccc4N3CCN(CCN(c1ccccn1)C(=O)C2CCCCC2)CC3
Target5-HT
SolubilityDMSO : ≥ 250 mg/mL 464.13 mM H2O : 25 mg/mL46.41 mM

Bioactivity

In Vivo
WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat. Animal model: Male Sprague-Dawley rats (220-240 g). Dosage: 1 mg/kg. Administration: Subcutaneous injection (Pharmacokinetic study). Result: Reduced total abstinence score, increased immobility time and the burying behavior was increased.
In Vitro
The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D2 L or D4.4 receptors. WAY-100635 displays 940, 370, and 16 nM binding affinities at D2 L, D3, and D4.2 receptors, respectively. Saturation analyses demonstrat that the Kd of [3H] WAY-100635 at D4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D4.4 cells with EC50 of 9.7 nM. WAY-100635 possesses high affinity for D4.4 receptor (3.3 nM).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

WAY 100635 | WAY-100635 | WAY100635 Maleate

Similar Products

  • WAY-100635 Monomaleate [orb1305242]

    >99.99% (May vary between batches)

    1092679-51-0

    538.64

    C25H34N4O2·C4H4O4

    2 mg, 5 mg, 10 mg, 25 mg, 100 mg, 500 mg, 200 mg, 50 mg, 1 ml x 10 mM (in DMSO)
  • WAY-100635 maleate [orb1695294]

    >99.99% (May vary between batches)

    634908-75-1

    538.645

    C25H34N4O2.xC4H4O4

    2 mg, 500 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
  • WAY-100635 maleate (b) [orb1224400]

    >98% (HPLC)

    634908-75-1

    538.6352

    C29H38N4O6

    500 mg, 1 g, 2 mg, 50 mg, 5 mg, 10 mg, 25 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

WAY-100635 Maleate (orb1223433)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,040.00
5 mg
¥ 1,430.00
10 mg
¥ 2,080.00
25 mg
¥ 3,510.00
50 mg
¥ 6,240.00
100 mg
¥ 9,100.00
500 mg
¥ 19,760.00