1-Methylxanthine

SKU: orb1310079

Description

1-Methylxanthine is a primary human urinary metabolite of caffeine and theophylline. This research compound is noted for its ability to enhance tumor cell radiosensitivity, making it relevant for in vitro and in vivo oncology studies investigating radiosensitization mechanisms.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	6136-37-4
MW	166.14
Purity	99.11% (May vary between batches)
Formula	C₆H₆N₄O₂
SMILES	CN1C(=O)NC2=C(NC=N2)C1=O
Target	Endogenous Metabolite
Solubility	DMSO:20 mg/mL (120.38 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.02 mM)

Bioactivity

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In Vitro

1-Methylxanthine exhibits similar activities to other naturally occurring methylxanthines. Unlike caffeine and theobromine, 3-Methylxanthine, and 1-methylxanthine do not occur naturally at high levels in plants. 1-Methylxanthine (3 mM; for 30 min) increases the radiation-induced clonogenic and apoptotic cell (RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53)) death.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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theophylline, urinary, tumor, 1Methylxanthine, 1-Methylxanthine, 1 Methylxanthine, caffeine, human, Human Endogenous Metabolite, Endogenous Metabolite, EndogenousMetabolite, metabolite, inhibit, Inhibitor

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Compound Identifiers

PubChem CID

80220 ↗

Key Properties

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No computed properties available.

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