16(R)-AFP 07 free acid

SKU: orb3134469

Description

Prostaglandin I2 is an unstable prostaglandin compound that inhibits platelet aggregation and induces vasodilation in the pulmonary vasculature via the "I prostanoid" (IP) receptor. AFP 07, a 7,7-difluoroprostacyclin derivative, serves as a selective and potent agonist for the IP receptor (Ki=0.561 nM). It exhibits weaker affinity for EP receptors, with a Ki value of > 100 nM for EP1-3 and > 10 nM for EP4. The compound 16(R)-AFP 07 free acid is an enantiomer of AFP 07. Its biological properties, particularly those involving IP and EP receptors, are yet to be fully assessed.

Images & Validation

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Key Properties

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CAS Number	773825-80-2
MW	412.47
Formula	C₂₂H₃₀F₂O₅
SMILES	C(=C/[C@@H]([C@H](CC#CCC)C)O)\[C@@H]1[C@@]2([C@@](O/C(=C\CCCC(O)=O)/C2(F)F)(C[C@H]1O)[H])[H]
Target	Prostaglandin Receptor

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Prostaglandin Receptor

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