2-BFI hydrochloride

SKU: orb1305898

Description

2-BFI hydrochloride is a potent and selective agonist of the I2-imidazoline receptor. Its application in research includes investigating neuroprotective mechanisms in models of ischemic stroke and modulating inflammatory responses in studies of acute immune diseases, both in vitro and in vivo.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	89196-95-2
MW	222.67
Purity	99.94%
Formula	C₁₁H₁₁ClN₂O
SMILES	Cl.N1=C(NCC1)C=2OC=3C=CC=CC3C2
Target	Imidazoline Receptor
Solubility	H2O:20 mg/mL (89.82 mM)

Bioactivity

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In Vivo

2-BFI hydrochloride administration after dMCAO improved the neurological deficits and decreased the infarct volume. 2-BFI hydrochloride reduced phosphorylation of mTOR and p70S6, increased IL-10 and TGF-β, and decreased IFN-γ levels in ischemic rats. 2-BFI hydrochloride attenuates ischemic injury by inhibiting the activation of mTOR signaling and modulating neuroinflammation after stroke in rats.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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I2-imidazoline receptor, ImidazolineReceptor, Imidazoline Receptor, 2 BFI hydrochloride, 2BFI hydrochloride, 2-BFI Hydrochloride

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Compound Identifiers

PubChem CID

45073465 ↗

Key Properties

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No computed properties available.

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