3-Hydroxy agomelatine

SKU: orb1992983

Description

3-Hydroxyagomelatine is a selective 5-HT2C receptor antagonist employed in neuroscience research. It is utilized in both in vitro binding assays and in vivo studies to investigate its potential role in neuropsychiatric conditions such as depression and anxiety disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	166526-99-4
MW	259.3
Purity	100.00%
Formula	C₁₅H₁₇NO₃
SMILES	O=C(NCCC1=CC(O)=CC2=CC=C(OC)C=C21)C
Target	5-HT Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (19.28 mM);DMSO:200 mg/mL (771.31 mM);H2O:80 mg/mL (308.52 mM)

Bioactivity

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Target IC50	5-HT2C receptor:1.8 μM (ki)\|5-HT2C receptor:3.2 μM
In Vivo	In Wistar rats, 3-Hydroxy agomelatine, administered by intraperitoneal injection at doses ranging from 1.25 to 40 mg/kg, did not significantly affect penile erections induced by mCPP and Ro 60-0175. Read more...
In Vitro	Agomelatine and S 21517 have relatively strong affinity for 5-HT2C receptors, with Ki values of 0.21 μM and 0.13 μM, respectively, while their metabolite 3-Hydroxy agomelatine has a lower affinity, with a Ki value of 1.8 μM, which is about 10-fold lower than that of the former two. All three are antagonists at the 5-HT2C receptor, and the order of potency is S 21517 > agomelatine > 3-Hydroxy agomelatine. Read more...

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5HTReceptor, 3-Hydroxyagomelatine, 3Hydroxy agomelatine, 3-Hydroxy agomelatine, 3 Hydroxy agomelatine, 5-HT2C Receptor, 5HT Receptor

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Compound Identifiers

PubChem CID

10400344 ↗

Key Properties

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No computed properties available.

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