4-Hydroxyretinoic acid

SKU: orb2279996

Description

4-Hydroxyretinoic acid (4-HRA) is a naturally occurring retinoid derivative with diverse biological effects. 4-Hydroxyretinoic acid is formed from retinol catalyzed by cytochrome P-450 isozyme(s), and is mainly metabolized by the liver in the body. 4-Hydroxyretinoic acid also serves as the substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. 4-Hydroxyretinoic acid regulates gene expression and cell differentiation via binding to nuclear receptor RAR (Retinoic Acid Receptor), and activates RARs and RXR-alpha, to induce cancer cell apoptosis. In addition, 4-Hydroxyretinoic acid is also involved in various physiological processes such as immune regulation, neuroprotection, and anti-oxidation.

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Key Properties

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CAS Number	66592-72-1
MW	316.43452
Purity	>98%
Formula	C₂₀H₂₈O₃
SMILES	OC(/C=C(/C=C/C=C(/C=C/C1=C(C)C(O)CCC1(C)C)\C)\C)=O

Storage & Handling

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Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

6438629 ↗

Key Properties

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No computed properties available.

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