5-Methyltryptamine hydrochloride

SKU: orb1710784

Description

5-Methyltryptamine hydrochloride is a partial agonist with high affinity for 5-HT1C receptors. Research indicates it exhibits protective effects in murine models of burn, tourniquet, and endotoxin shock, supporting its use in studying serotonin pharmacology and shock pathophysiology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1010-95-3
MW	210.703
Purity	99.45%
Formula	C₁₁H₁₅ClN₂
SMILES	Cl.CC1=CC=C2NC=C(CCN)C2=C1
Target	5-HT Receptor
Solubility	DMSO:Soluble

Bioactivity

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In Vivo	5-Methyltryptamine contracts trachea with lower potency (-log EC50 < 5) than 5-HT (-log EC50 = 6.98). Guinea pig tracheal contraction to 5-HT and 5-Methyltryptamine is inhibited by 1-(1-naphthyl)piperazine (1-NP, 30 nM). Read more...
In Vitro	5-Methyltryptamine stimulates breakdown of endogenous [3H]inositol-labeled phosphoinositides in membranes prepared from blowfly salivary gland homogenates. 5-Methyltryptamine, in the presence of 10 microM GTP gamma S, increased the rate of inositol trisphosphate formation by approximately 500% within 30 s. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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a-helical CRF 9-41 acetate(90880-23-2 Free base), 5-HT1C, 5-HT, 5HT Receptor, 5HTReceptor, 5-Methyltryptamine Hydrochloride, 2-(5-Methyl-1H-indol-3-yl)ethanamine hydrochloride, α-helical CRF 9-41 acetate(90880-23-2 Free base), α-helical CRF 9-41 acetate(90880-23-2 Free base)

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Compound Identifiers

PubChem CID

6917145 ↗

Key Properties

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No computed properties available.

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